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Génétique Quantitative et Évolution - Le Moulon

 Hadi QUESNEVILLE (INRAE, URGI, Versailles) (invité·e par Clémentine Vitte)

  -  12:00:00
 GQE-Le Moulon
 https://office.moulon.inra.fr/nextcloud/index.php/apps/bbb/b/dLqERp26waz5iw9L

Traces of transposable elements in genome dark matter co-opted by flowering gene regulation networks

Résumé

Transposable elements (TEs) are mobile, repetitive DNA sequences that make the largest contribution to genome bulk. They thus contribute to the so-called “dark matter of the genome”, the part of the genome in which nothing is immediately recognizable as biologically functional.

We developed a new method, based on k-mers, to identify degenerate TE sequences. With this new algorithm, we detect up to 10% of the A. thaliana genome as derived from as yet unidentified TEs, bringing the proportion of the genome known to be derived from TEs up to 50%.

A significant proportion of these sequences overlapped conserved non-coding sequences identified in crucifers and rosids, and transcription factor binding sites. They are overrepresented in some gene regulation networks, such as the flowering gene network, suggesting a functional role for these sequences that have been conserved for more than 100 million years, since the spread of flowering plants in the Cretaceous.