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Génétique Quantitative et Évolution - Le Moulon

Christine DILLMANN

Christine DILLMANN

Professor, Université Paris-Saclay, Faculté des Sciences


+33 (0)1 69 33 23 48


  • Génétique Quantitative et Évolution - Le Moulon
  • Université Paris-Saclay, INRAE, CNRS, AgroParisTech
  • 12 route 128
  • 91190 Gif-sur-Yvette


  • Professor at Université Paris-Saclay
  • Head of BASE team (2001-2019)
  • Head of the lab Quantitative Genetics & Evolution - Le Moulon (2019-)

Research interests

I am interested in understanding the causes of phenotypic variation within populations, and the (co)evolution of genetic polymorphism and phenotypic variation.


Research and University management

  • Member of the Council of the Biology department, Faculté des Sciences, Université Paris-Sud (2012-2016).
  • Member of the research council of Université Paris-Sud (2016-2019).
  • Actively involved in the evaluation of research: CCSU, Université Paris-Sud ; CSS GVA (researchers) and CEI (engineers) INRA.


  • Coton C., Dillmann C. , de Vienne D.. (2023) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2. Journal of Theoretical Biology, (558) 111354
  • Desbiez-Piat A., Ressayre A., Marchadier E., Noly A., Remoue C., Vitte C., Belcram H., Bourgais A., Galic N., Guilloux ML., Tenaillon MI., Dillmann C. . (2023) Pervasive GxE interactions shape adaptive trajectories and the exploration of the phenotypic space in artificial selection experiments. Genetics, (in press) 2023.01.13.523786
  • de Vienne D., Coton C., Dillmann C. . (2023) The genotype–phenotype relationship and evolutionary genetics in the light of the Metabolic Control Analysis. Biosystems, (232) 105000
  • Coton C., Talbot G., Le Louarn M., Dillmann C. , de Vienne D.. (2022) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1. Journal of Theoretical Biology, (538) 111015
  • Coton C., 2021-12, Évolution des concentrations d'enzymes dans les réseaux métaboliques, Theses, Université Paris-Saclay
  • David O., Le Rouzic A., Dillmann C. . (2022) Optimization of sampling designs for pedigrees and association studies. Biometrics, 3 (78) 1056-1066
  • Desbiez-Piat A., Le Rouzic A., Tenaillon MI., Dillmann C. . (2021) Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations. Genetics, 2 (219)
  • Desbiez-Piat, 2021, The Dynamics of the Response to Selection under High Drift-High Selection: Insights from Saclay’s Divergent Selection Experiments for Flowering Time in Maize, PhD Thesis, Université Paris-Saclay
  • Petrizzelli MS., de Vienne D., Nidelet T., Noûs C., Dillmann C. , Kaleta C.. (2021) Data integration uncovers the metabolic bases of phenotypic variation in yeast. PLoS Comput Biol, 7 (17) e1009157
  • Plancade S., Marchadier E., Huet S., Ressayre A., Noûs C., Dillmann C. . (2021) A new hypothesis-testing model for phyllochron based on a stochastic process - application to analysis of genetic and environment effects in maize. DOI.org (Crossref),
  • Sanané I., Legrand J., Dillmann C. , Marion-Poll F.. (2021) High-Throughput Feeding Bioassay for Lepidoptera Larvae. J Chem Ecol, 7 (47) 642-652
  • Sanane I., 20 octobre 2020, Composantes de la dynamique de l’interaction entre le maïs et les insectes lépidoptères foreurs de tige, PhD thesis, Université Paris-Saclay
  • Petrizzelli M., de Vienne D., Dillmann C. . (2019) Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast’s Life-History and Proteomic Traits. Genetics, 2 (211) 741-756
  • Petrizzelli M., 2019-07, Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast, Theses, Université Paris Saclay (COmUE)
  • Tenaillon MI., Seddiki K., Mollion M., Guilloux ML., Marchadier E., Ressayre A., Dillmann C. . (2019) Transcriptomic response to divergent selection for flowering times reveals convergence and key players of the underlying gene regulatory network. bioRxiv, 461947
  • Albert B., Ressayre A., Dillmann C. , Carlson AL., Swanson RJ., Gouyon PH., Dobritsa AA.. (2018) Effect of aperture number on pollen germination, survival and reproductive success in Arabidopsis thaliana. Ann. Bot., 4 (121) 733-740
  • Collot D., Nidelet T., Ramsayer J., Martin OC., Meleard S., Dillmann C. , Sicard D., Legrand J.. (2018) Feedback between environment and traits under selection in a seasonal environment: consequences for experimental evolution. Proceedings. Biological sciences, 1876 (285)
  • Collot D., 2018-06-19 19/06/18, Modélisation des dynamiques adaptatives de la levure de boulanger S. cerevisae dans un environnement saisonnier, PhD thesis, Université Paris-Saclay
  • Fiévet JB., Nidelet T., Dillmann C. , de Vienne D.. (2018) Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. Front. Genet., (9)
  • Reboud X., Sicard D., Bataillon T., Bedhomme S., Dillmann C. , Gaba S., Gallet R., Guidot A., Goldringer I., Jasmin JN., Kaltz O., Méry F., Nidelet T., Schneider D., Spor A., Thomas F., Raymond M., Lefevre T.. (2016) Évolution expérimentale. , 755-790
  • Sabarly V., Aubron C., Glodt J., Balliau T., Langella O., Chevret D., Rigal O., Bourgais A., Picard B., de Vienne D., Denamur E., Bouvet O., Dillmann C. . (2016) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environmental microbiology, 1 (18) 100-17
  • Blein-Nicolas M., Albertin W., da Silva T., Valot B., Balliau T., Masneuf-Pomarède I., Bely M., Marullo P., Sicard D., Dillmann C. , de Vienne D., Zivy M.. (2015) A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast. Mol. Cell Proteomics, 8 (14) 2056-2071
  • Durand E., Tenaillon MI., Raffoux X., Thépot S., Falque M., Jamin P., Bourgais A., Ressayre A., Dillmann C. . (2015) Dearth of polymorphism associated with a sustained response to selection for flowering time in maize. BMC Evol Biol, 1 (15) 103
  • Ressayre A., Glemin S., Montalent P., Serre-Giardi L., Dillmann C. , Joets J.. (2015) Introns Structure Patterns of Variation in Nucleotide Composition in Arabidopsis thaliana and Rice Protein-Coding Genes. Genome biology and evolution, 10 (7) 2913-28
  • da Silva T., Albertin W., Dillmann C. , Bely M., la Guerche S., Giraud C., Huet S., Sicard D., Masneuf-Pomarede I., de Vienne D., Marullo P.. (2015) Hybridization within Saccharomyces Genus Results in Homoeostasis and Phenotypic Novelty in Winemaking Conditions. PloS one, 5 (10) e0123834
  • Spor A., Kvitek DJ., Nidelet T., Martin J., Legrand J., Dillmann C. , Bourgais A., de Vienne D., Sherlock G., Sicard D.. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast. Evolution; international journal of organic evolution, 3 (68) 772-90
  • Albertin W., Marullo P., Bely M., Aigle M., Bourgais A., Langella O., Balliau T., Chevret D., Valot B., da Silva T., Dillmann C. , de Vienne D., Sicard D.. (2013) Linking post-translational modifications and variation of phenotypic traits. Molecular & cellular proteomics : MCP, 3 (12) 720-35
  • Blein-Nicolas M., Albertin W., Valot B., Marullo P., Sicard D., Giraud C., Huet S., Bourgais A., Dillmann C. , de Vienne D., Zivy M.. (2013) Yeast proteome variations reveal different adaptive responses to grape must fermentation. Molecular biology and evolution, 6 (30) 1368-83
  • Durand E., Bouchet S., Bertin P., Ressayre A., Jamin P., Charcosset A., Dillmann C. , Tenaillon MI.. (2012) Flowering time in maize: linkage and epistasis at a major effect locus. Genetics, 4 (190) 1547-62
  • Albertin W., Marullo P., Aigle M., Dillmann C. , de Vienne D., Bely M., Sicard D.. (2011) Population size drives industrial Saccharomyces cerevisiae alcoholic fermentation and is under genetic control. Applied and environmental microbiology, 8 (77) 2772-84
  • Sabarly V., Bouvet O., Glodt J., Clermont O., Skurnik D., Diancourt L., de Vienne D., Denamur E., Dillmann C. . (2011) The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity. Journal of evolutionary biology, 7 (24) 1559-71
  • Wang S., Spor A., Nidelet T., Montalent P., Dillmann C. , de Vienne D., Sicard D.. (2011) Switch between life history strategies due to changes in glycolytic enzyme gene dosage in Saccharomyces cerevisiae. Applied and environmental microbiology, 2 (77) 452-9
  • Durand E., Tenaillon MI., Ridel C., Coubriche D., Jamin P., Jouanne S., Ressayre A., Charcosset A., Dillmann C. . (2010) Standing variation and new mutations both contribute to a fast response to selection for flowering time in maize inbreds. BMC evolutionary biology, (10) 2
  • Fievet JB., Dillmann C. , de Vienne D.. (2010) Systemic properties of metabolic networks lead to an epistasis-based model for heterosis. Theor Appl Genet, 2 (120) 463-73
  • Spor A., Dillmann C. , Wang S., de Vienne D., Sicard D., Parent E.. (2010) Hierarchical Bayesian Modelling for Saccharomyces cerevisiae population dynamics. International journal of food microbiology, 1-2 (142) 25-35
  • Albertin W., Marullo P., Aigle M., Bourgais A., Bely M., Dillmann C. , de Vienne D., Sicard D.. (2009) Evidence for autotetraploidy associated with reproductive isolation in Saccharomyces cerevisiae: towards a new domesticated species. Journal of evolutionary biology, 11 (22) 2157-70
  • Edelist C., Raffoux X., Falque M., Dillmann C. , Sicard D., Rieseberg LH., Karrenberg S.. (2009) Differential expression of candidate salt-tolerance genes in the halophyte Helianthus paradoxus and its glycophyte progenitors H. annuus and H. petiolaris (Asteraceae). American journal of botany, 10 (96) 1830-8
  • Spor A., Wang S., Dillmann C. , de Vienne D., Sicard D.. (2008) "Ant" and "grasshopper" life-history strategies in Saccharomyces cerevisiae. PloS one, 2 (3) e1579