Olivier LANGELLA
Engineer, CNRS
olivier.langella@universite-paris-saclay.fr
+33 (0)1 69 33 23 68
- Génétique Quantitative et Évolution - Le Moulon
- Université Paris-Saclay, INRAE, CNRS, AgroParisTech
- Ferme du Moulon
- F-91190 Gif-sur-Yvette
Position and Education
- CNRS research engineer, GQE-Le Moulon (Gif-sur-Yvette, France), 2004-present
- CNRS engineer, EGCE (Gif-sur-Yvette, France), 1996-2003
- Bioinformatics post graduate degree (Université Pierre et Marie Curie, Paris VI), 1995
Research interests
I am interested in computational challenges raised by highthroughtput proteomics studies (data storage and intensive calculation). In charge of the bioinformatics developments of the PAPPSO team, I thus lead several projects :
- MassChroQ ( Valot et al. 2011), mass spectrometry based quantification software
- X!TandemPipeline ( Langella et al. 2017), for protein inference
- PROTICdb ( Langella et al. 2013), proteomic database to store, publish and query proteomics data
We have developped a complete solution using free softwares and common hardware to store 10Tbytes per year and offering high speed connection to an HPC cluster (based on ceph and HTCondor).
I am also involved in the GQE Bioinformatics facility (ABI), in which I lead the ABI-SYS group (system).
Publications
Langella O, Valot B, Balliau T, Blein-Nicolas M, Bonhomme L, Zivy M.
(2017)
X!TandemPipeline: A Tool to Manage Sequence Redundancy for Protein Inference and Phosphosite Identification.
J. Proteome Res., 2 (16) 494-503
Sabarly V, Aubron C, Glodt J, Balliau T, Langella O, Chevret D, Rigal O, Bourgais A, Picard B, de Vienne D, Denamur E, Bouvet O, Dillmann C.
(2016)
Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates.
Environmental microbiology, 1 (18) 100-17
Albertin W, Marullo P, Bely M, Aigle M, Bourgais A, Langella O, Balliau T, Chevret D, Valot B, da Silva T, Dillmann C, de Vienne D, Sicard D.
(2013)
Linking post-translational modifications and variation of phenotypic traits.
Molecular & cellular proteomics : MCP, 3 (12) 720-35
Langella O, Valot B, Jacob D, Balliau T, Flores R, Hoogland C, Joets J, Zivy M.
(2013)
Management and dissemination of MS proteomic data with PROTICdb: Example of a quantitative comparison between methods of protein extraction.
Proteomics, 9 (13) 1457-66
Valot B, Langella O, Nano E, Zivy M.
(2011)
MassChroQ: a versatile tool for mass spectrometry quantification.
Proteomics, 17 (11) 3572-7