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Génétique Quantitative et Évolution - Le Moulon

BASE - Biology and Adaptation, Systems in Evolution

illustration des thématiques
maïs : panicule et expérimentation

We aim at modeling the complexity of genotype-phenotype map and its evolutionary consequences to better understand how a population adapts to a new environment. The originality of the team is to develop both modeling and experimental approaches to integrate the variety of mechanisms that sustain evolution.

Our favorite model species are bakery yeast (Saccharomyces cerevisiae) and corn (Zea mays mays).

Genome dynamics

Some traits like recombination rate, gene architecture and mating system are submitted to selection at the species level and condition present genetic diversity.

Variability in life history traits and genotype-phenotype maps

The complex inheritance of life-history traits emerge from the functioning of genes and metabolic networks throughout development. How to predict the genotype-phenotype relationship from genes and gene products ?

Dynamics of adaptation

How do biological networks (genes, metabolism, proteins) evolve within a population ? Which relationship with the evolution of life-history traits ?

BASE is attached to the LabEx BASC, Biodiversité, Agroécosystèmes, Société, Climat.


  • Willy Vincent Bienvenut Junior Investigator (CNRS)
  • Mélisande Blein-Nicolas Engineer (INRAE)
  • Charlotte Coton PhD student (Université Paris-Saclay)
  • Dominique de Vienne Professor (Université Paris-Saclay)
  • Christine Dillmann Professor (Université Paris-Saclay, Faculté des Sciences)
  • Matthieu Falque Engineer (INRAE)
  • Nathalie Galic (INRAE)
  • Édith Garot Postdoctoral fellow (INRAE)
  • Judith Legrand Assistant professor (Université Paris-Saclay)
  • Élodie Marchadier Assistant Professor (Université Paris-Saclay)
  • Xavier Raffoux Technician (INRAE)
  • Adrienne Ressayre (INRAE)
  • Inoussa Sanané PhD student (Université Paris-Saclay)
  • Élise Tourrette Postdoctoral fellow (INRAE)
  • Adrien Vidal Ingénieur d'études, CDD (INRAE)
  • Michel Zivy Directeur de Recherche (CNRS)


Falque M, Jebreen K, Paux E, Knaak C, Mezmouk S, Martin OC. (2020) CNVmap: A Method and Software To Detect and Map Copy Number Variants from Segregation Data. Genetics, 3 (214) 561-576
Bienvenut W, 2 décembre 2019, Des débuts de la protéomique à l'acétylation N-terminale des protéines chez les plantes
Jebreen K, Petrizzelli M, Martin OC. (2019) Probabilities of Multilocus Genotypes in SIB Recombinant Inbred Lines. Front. Genet., (10) 833
Petrizzelli M, de Vienne D, Dillmann C. (2019) Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast's Life-History and Proteomic Traits. Genetics, 2 (211) 741-756
Petrizzelli M, 8 juillet 2019, Mathematical modelling and integration of complex biological data: analysis of the heterosis phenomenon in yeas
Srisuwan S, Sihachakr D, Martin J, Valles J, Ressayre A, Brown SC, Siljak-Yakovlev S. (2019) Change in nuclear DNA content and pollen size with polyploidisation in the sweet potato (Ipomoea batatas, Convolvulaceae) complex. Plant Biol (Stuttg), 2 (21) 237-247
Termolino P, Falque M, Aiese Cigliano R, Cremona G, Paparo R, Ederveen A, Martin OC, Consiglio FM, Conicella C. (2019) Recombination suppression in heterozygotes for a pericentric inversion induces the interchromosomal effect on crossovers in Arabidopsis. Plant J, 6 (100) 1163-1175
Tourrette E, 25 novembre 2019, Unleashing genetic diversity in breeding by increasing recombination: an in silico study
Tourrette E, Bernardo R, Falque M, Martin OC. (2019) Assessing by Modeling the Consequences of Increased Recombination in Recurrent Selection of Oryza sativa and Brassica rapa. G3, g3.400545.2019
Urien C, Legrand J, Montalent P, Casaregola S, Sicard D. (2019) Fungal Species Diversity in French Bread Sourdoughs Made of Organic Wheat Flour. Front. Microbiol., (10) 201
Vasseur F, Fouqueau L, de Vienne D, Nidelet T, Violle C, Weigel D. (2019) Nonlinear phenotypic variation uncovers the emergence of heterosis in Arabidopsis thaliana. PLoS Biol, 4 (17) e3000214
Albert B, Ressayre A, Dillmann C, Carlson AL, Swanson RJ, Gouyon PH, Dobritsa AA. (2018) Effect of aperture number on pollen germination, survival and reproductive success in Arabidopsis thaliana. Ann. Bot., 4 (121) 733-740
Carbonetto B, Ramsayer J, Nidelet T, Legrand J, Sicard D. (2018) Bakery yeasts, a new model for studies in ecology and evolution. Yeast, 11 (35) 591-603
Collot D, Nidelet T, Ramsayer J, Martin OC, Meleard S, Dillmann C, Sicard D, Legrand J. (2018) Feedback between environment and traits under selection in a seasonal environment: consequences for experimental evolution. Proceedings. Biological sciences, 1876 (285)
Fiévet JB, Nidelet T, Dillmann C, de Vienne D. (2018) Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. Front. Genet., (9)
Raffoux X, 2018-06-11 06/11/18, Diversité et déterminisme génétique de la recombinaison méiotique chez Saccharomyces cerevisiae
Raffoux X, Bourge M, Dumas F, Martin OC, Falque M. (2018) High-throughput measurement of recombination rates and genetic interference in Saccharomyces cerevisiae. Yeast, 6 (35) 431-442
Raffoux X, Bourge M, Dumas F, Martin OC, Falque M. (2018) Role of cis, trans, and Inbreeding Effects on Meiotic Recombination in Saccharomyces cerevisiae. Genetics, 4 (210) 1213-1226
Giraud H, Bauland C, Falque M, Madur D, Combes V, Jamin P, Monteil C, Laborde J, Palaffre C, Gaillard A, Blanchard P, Charcosset A, Moreau L. (2017) Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.). G3: Genes, Genomes, Genetics, g3.300121.2017
Henry VJ, Saïs F, Marchadier E, Dibie J, Goelzer A, Fromion V. (2017) BiPOm: Biological interlocked Process Ontology for metabolism. How to infer molecule knowledge from biological process?. , np
Pelé A, Falque M, Trotoux G, Eber F, Nègre S, Gilet M, Huteau V, Lodé M, Jousseaume T, Dechaumet S, Morice J, Poncet C, Coriton O, Martin OC, Rousseau-Gueutin M, Chèvre AM. (2017) Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas. PLoS Genet, 5 (13)
Sabarly V, Aubron C, Glodt J, Balliau T, Langella O, Chevret D, Rigal O, Bourgais A, Picard B, de Vienne D, Denamur E, Bouvet O, Dillmann C. (2016) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environmental microbiology, 1 (18) 100-17
Blein-Nicolas M, Albertin W, da Silva T, Valot B, Balliau T, Masneuf-Pomarède I, Bely M, Marullo P, Sicard D, Dillmann C, de Vienne D, Zivy M. (2015) A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast. Mol. Cell Proteomics, 8 (14) 2056-2071
Falque M, 2015-10-15 15/10/15, Sur les traces de la recombinaison méiotique, source de biodiversité et outil génétique
Sidhu GK, Fang C, Olson MA, Falque M, Martin OC, Pawlowski WP. (2015) Recombination patterns in maize reveal limits to crossover homeostasis. PNAS, 52 (112) 15982-15987
da Silva T, Albertin W, Dillmann C, Bely M, la Guerche S, Giraud C, Huet S, Sicard D, Masneuf-Pomarede I, de Vienne D, Marullo P. (2015) Hybridization within Saccharomyces Genus Results in Homoeostasis and Phenotypic Novelty in Winemaking Conditions. PloS one, 5 (10) e0123834
Spor A, Kvitek DJ, Nidelet T, Martin J, Legrand J, Dillmann C, Bourgais A, de Vienne D, Sherlock G, Sicard D. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast. Evolution; international journal of organic evolution, 3 (68) 772-90
Albertin W, da Silva T, Rigoulet M, Salin B, Masneuf-Pomarede I, de Vienne D, Sicard D, Bely M, Marullo P. (2013) The mitochondrial genome impacts respiration but not fermentation in interspecific Saccharomyces hybrids. PloS one, 9 (8) e75121
Albertin W, Marullo P, Bely M, Aigle M, Bourgais A, Langella O, Balliau T, Chevret D, Valot B, da Silva T, Dillmann C, de Vienne D, Sicard D. (2013) Linking post-translational modifications and variation of phenotypic traits. Molecular & cellular proteomics : MCP, 3 (12) 720-35
Blein-Nicolas M, Albertin W, Valot B, Marullo P, Sicard D, Giraud C, Huet S, Bourgais A, Dillmann C, de Vienne D, Zivy M. (2013) Yeast proteome variations reveal different adaptive responses to grape must fermentation. Molecular biology and evolution, 6 (30) 1368-83
Blein-Nicolas M, Xu H, de Vienne D, Giraud C, Huet S, Zivy M. (2012) Including shared peptides for estimating protein abundances: a significant improvement for quantitative proteomics. Proteomics, 18 (12) 2797-801
Albertin W, Marullo P, Aigle M, Dillmann C, de Vienne D, Bely M, Sicard D. (2011) Population size drives industrial Saccharomyces cerevisiae alcoholic fermentation and is under genetic control. Applied and environmental microbiology, 8 (77) 2772-84
Fiévet JB, Gallais A, de Vienne D, Prioul JL, Thévenot C, Molnar T, Mike Burrel . (2011) Heterosis, inbreeding depression and hybrid varieties. , 67-87
Gauthier F, Martin O, Falque M. (2011) CODA (crossover distribution analyzer): quantitative characterization of crossover position patterns along chromosomes. BMC Bioinformatics, 1 (12) 27
Sabarly V, Bouvet O, Glodt J, Clermont O, Skurnik D, Diancourt L, de Vienne D, Denamur E, Dillmann C. (2011) The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity. Journal of evolutionary biology, 7 (24) 1559-71
Wang S, Spor A, Nidelet T, Montalent P, Dillmann C, de Vienne D, Sicard D. (2011) Switch between life history strategies due to changes in glycolytic enzyme gene dosage in Saccharomyces cerevisiae. Applied and environmental microbiology, 2 (77) 452-9